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| Linkage interval >> Method >> Network & Known Disease Genes >> Results |
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The GeneWanderer is a computational method to prioritise a set of candidate genes by probability to
be involved in particular disease or phenotype.
Our approach measures the relative location of each candidate
gene in a genomic interval (e.g. found by linkage analysis) to genes known to be involved in the phenotype/disease
under investigation in a huge protein-protein interaction (PPI) network. By using the random walk or diffusion kernel global
characeristics of the network are taken into account. The shortest path and direct interaction method use local properties
of the PPI-network.
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If you use this tool, please cite:
Köhler et al. Walking the interactome for prioritization of candidate disease genes. Am J Hum Genet (2008) |
A comparison (showing the great performance of GeneWanderer) of different network-based approaches can be found in:
Navlakha and Kingsford. The Power of Protein Interaction Networks for Associating Genes with Diseases. Bioinformatics (2010) |
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