| GeneWanderer |
| > GeneWanderer |
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| Linkage interval >> Method >> Network & Known Disease Genes >> Results |
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The GeneWanderer is a computational method to prioritise a set
of candidate genes according to their probability of being involved in
particular disease or phenotype. Our approach measures the relative location of each candidate gene in a genomic interval (identified by linkage analysis or other methods) to genes known to be involved in the phenotype/disease under investigation in the protein-protein interaction (PPI) network. By using the random walk or diffusion kernel global characeristics of the network are taken into account. The shortest path and direct interaction method use local properties of the PPI-network. |
If you use this tool, please cite:
Köhler et al., Walking the Interactome for Prioritization of Candidate Disease Genes,
The American Journal of Human Genetics 82, 949-958, April 2008